Basis: Based on inadequate human and animal data. Epidemiologic studies failed to show a correlation between exposure to elemental mercury vapor and carcinogenicity; the findings in these studies were confounded by possible or known concurrent exposures to other chemicals, including human carcinogens, as well as …
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Note: Any future dates displayed in the table above should be considered estimates and are subject to change. Once the external peer review is complete, estimated dates for release of the final assessment will be published. For the latest information on the status of this assessment, please refer to the IRIS Program Outlook.To access assessment …
Basis: Observation of increased incidence of bladder cancer and bladder cancer-related deaths in exposed workers; This may be a synopsis of the full weight-of-evidence narrative.
Using U.S. EPA's revised draft 1999 Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), diesel exhaust (DE) is likely to be carcinogenic to humans by inhalation from environmental exposures. This may be a synopsis of the full weight-of-evidence narrative.
Additional EPA toxicity information may be available by visiting the following sites: Human Health Benchmarks for Pesticides (HHBP).This database provides human health benchmarks for pesticides that may be present in drinking water.
System RfD (mg/kg-day) Basis PoD Composite UF Confidence; Developmental: 5 x 10 -4 (Chronic) Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and rats
WOE Characterization Framework for WOE Characterization; B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
United States Environmental Protection Agency. Search Search. Main menu. Environmental Topics ... Menu. Environmental Topics; Laws & Regulations; About EPA; IRIS. Contact Us; Molybdenum CASRN 7439-98-7 | DTXSID1024207 IRIS Summary (PDF) (11 pp, 106 K) Key IRIS Values; Other EPA Information; Noncancer Assessment. …
System RfD (mg/kg-day) Basis PoD Composite UF Confidence; Developmental, Immune: 2 x 10 -9 (Chronic) Decreased serum antibody concentrations for tetanus and diphtheria in children; …
Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) Basis: Existing studies are inadequate to assess the carcinogenicity of manganese. This may …
CASRN 7440-38-2 | DTXSID4023886 IRIS Summary (PDF) (29 pp, 186 K) Workshop & meeting details from the development of the draft IRIS Assessment for …
US EPA. United States Environmental Protection Agency. Search ... About EPA; IRIS. Contact Us; 1,2,4-Trimethylbenzene CASRN 95-63-6 | DTXSID6021402 Toxicological Review (PDF) (150 pp, 2.65 M) IRIS Executive Summary (PDF) (10 pp, 323 K) Supplemental Information on the IRIS Toxicological Review of Trimethylbenzene ...
This IRIS assessment for Benzo[k]fluoranthene consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions.
On the basis of sufficient evidence for carcinogenicity in human epidemiology studies, VC is considered to best fit the weight-of-evidence Category "A," according to current EPA Risk Assessment Guidelines (U.S. EPA, 1986).
Basis: Sufficient animal evidence. Ten rat bioassays and one mouse assay have shown statistically significant increases in renal tumors with dietary and subcutaneous exposure to several soluble lead salts.
This IRIS assessment for 1,3-Butadiene consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions.
Oral Slope Factor: 4.6 x 10-2 per mg/kg-day Extrapolation Method: PBPK model-based route-to-route extrapolation of the inhalation unit risk estimate for kidney cancer with a factor of 5 applied to include non-Hodgkin's lymphoma (NHL) and liver cancer risks, combined risk
Under EPA's Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), Cr(VI) is "likely to be carcinogenic" via oral exposure based on sufficiently supported [laboratory] animal studies relevant to …
This page provides a list of final IRIS assessments in alphabetical order by chemical name.
Basis: Based on inadequate data in humans and limited evidence of carcinogenicity in animals. Male ICR and B6C3F1 mice exposed to methylmercuric chloride in the diet had an increased incidence of renal …
Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is inadequate information to assess the carcinogenic potential of toluene because studies of humans chronically exposed to toluene are inconclusive, toluene was not carcinogenic in adequate inhalation cancer bioassays of rats and mice exposed for life …
This IRIS assessment for Maneb consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions.
Basis: In animals, local sarcomas have been induced after implantation of foils and discs of silver. However, the interpretation of these findings has been questioned due to the phenomenon of solid-state carcinogenesis in which even insoluble solids such as plastic have been shown to result in local fibrosarcomas.
IRIS Summary (PDF) (8 pp, 93 K) Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the …
System RfD (mg/kg-day) Basis PoD Composite UF Confidence; Immune, Hematologic: 3 x 10 -1: Decreases in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity in healthy adult male and volunteers
This IRIS assessment for Benzaldehyde consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions.
Note: The RfD for 1,2,3-TMB is based on data for 1,2,4-TMB and route-to-route extrapolation.See Section 2.2.3 of the Toxicological Review for additional details.
19 rowsThe Integrated Risk Information System (IRIS) is a data base that contains EPA scientific consensus positions on potential human health effects from …